Immune responses in neonates
نویسندگان
چکیده
منابع مشابه
Different Immune Responses in Dangerous O Blood Donors
Background & Objective: Dangerous O is very important to transfusion medicine and there has been reports by Food and Drug Administration (FDA) regarding some death relating incidences. As high iso-antibody production is closely associated with different immune reactions, a survey on the different immune response of dangerous O donors can lead to understanding their immune respo...
متن کاملDecreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates.
Neonates have an increased rate of infection with encapsulated bacteria compared with older children and adults because of diminished antibody responses to T-independent (TI) antigens such as bacterial polysaccharides. Because the interactions of tumor necrosis factor (TNF) family ligands BAFF and APRIL with the TNF family receptors (TNFRs) TACI, BCMA, and BAFF-R are crucial to TI antibody resp...
متن کاملImmune development in late preterm neonates
Several recent studies have underlined that late preterm infants have a significantly increased risk of infection and sepsis, [1-3] mainly related to problems of adaptation from intrato extra-uterine life of the immune defense mechanisms. Indeed, both the innate (natural, non specific) and the adaptive (acquired, specific) immune systems are incompletely developed at birth, the more preterm the...
متن کاملImmune status in very preterm neonates.
OBJECTIVES Preterm neonates are at increased risk of sepsis compared with those born at term. We investigated immune status at birth and early neonatal life in very preterm neonates and its association with short-term outcomes. METHODS Prospective observational study conducted at a university hospital recruiting 113 preterm neonates (23-32 weeks) and 78 controls. Monocyte major histocompatibi...
متن کاملHigh expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates.
The vulnerability to infection of newborns is associated with a limited ability to mount efficient immune responses. High concentrations of adenosine and prostaglandins in the fetal and neonatal circulation hamper the antimicrobial responses of newborn immune cells. However, the existence of mechanisms counterbalancing neonatal immunosuppression has not been investigated. Remarkably, circulatin...
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ژورنال
عنوان ژورنال: Expert Review of Clinical Immunology
سال: 2014
ISSN: 1744-666X,1744-8409
DOI: 10.1586/1744666x.2014.942288